Sergey Irkhin

Sergey Irkhin

Senior manager of promotion department Dia-M LLC


Time and date Venue Topic Speakers

Wednesday 20/11/2019

From 16:20 To 16:50

11/20/2019 16:20 11/20/2019 16:50 High-throughput glycan screening of crude and purified samples Glycosylation is considered among the most important post-translational modifications when developing new biologics. Having a significant impact on product performance and variability, glycosylation is a critical quality attribute (CQA) influencing product safety and efficacy. Protein glycosylation can affect isolation and purification steps (process consistency), pharmacokinetics (half-life) properties and in vitro stability (product shelf-life). Sialic acid content is especially important as it can impact the stability and clearance of a protein.
ForteBio’s Sialic Acid (GlyS) Kit provides a rapid and convenient method for relative screening of terminal sialic acid content in crude or purified samples. Sialic acid data can be combined with titer data using Octet Data Analysis HT software version 11.1 or higher to funnel through samples that are high producers and have desirable sialic acid content.
Conference Hall L, Hall 7, Pavillion 2

Conference Hall L, Hall 7, Pavillion 2

"High-throughput glycan screening of crude and purified samples"

Sergey Irkhin
Time and date

Wednesday 20/11/2019

From 16:20 To 16:50

11/20/2019 16:20 11/20/2019 16:50 High-throughput glycan screening of crude and purified samples Glycosylation is considered among the most important post-translational modifications when developing new biologics. Having a significant impact on product performance and variability, glycosylation is a critical quality attribute (CQA) influencing product safety and efficacy. Protein glycosylation can affect isolation and purification steps (process consistency), pharmacokinetics (half-life) properties and in vitro stability (product shelf-life). Sialic acid content is especially important as it can impact the stability and clearance of a protein.
ForteBio’s Sialic Acid (GlyS) Kit provides a rapid and convenient method for relative screening of terminal sialic acid content in crude or purified samples. Sialic acid data can be combined with titer data using Octet Data Analysis HT software version 11.1 or higher to funnel through samples that are high producers and have desirable sialic acid content.
Conference Hall L, Hall 7, Pavillion 2
Venue

Conference Hall L, Hall 7, Pavillion 2

Topic
Speakers