Hiroyasu Kokubo

Hypromellose as Versatile Excipients for Solid Dosage Forms in Granulation, Coating and Sustained Release
Dr. Hiroyasu Kokubo, Shinetsu, Japan

Pharmtech 2006
Moscow, 21st of November 2006

Abstract — Draft

Shinetsu presents the following products to the world pharmaceutical market:

Trade name METOLOSE® (USP, PhEur, JP) METOLOSE® SR (USP, PhEur, JP) Pharmacoat® (USP, PhEur, JP) HPMCP® (NF, PhEur, JP) Shin-Etsu AQOAT® (NF, JPE) L-HPC® (NF, JP)  Hypromellose as Various Functions

Generic name Hypromellose & Methylcellulose Hypromellose Phthalate Hypromellose Acetate Succinate Low-Substitute Hydroxypropylcellulose

• Binder
  o HPMC has good binding ability, which also can improve compressibility of the powders.



• Film coating
  o HPMC films are flexible and though, which can fulfill most of the film coating requirement.



• Sustained release (matrix agent)
  o METOLOSE^® SR is designed for matrix tablet having finer particle size and tighter substitution ranges with good lot to lot consistency under GMP controlling.

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